Ammonium formate → HCID 54406415, compound

Participants

Reaction Steps

Ethyl 4-[2-oxo-2-(3-pyridyl)ethyl]cinnamate (1.0 g) and ammonium formate (4.28 g) were stirred at 140° C. for four hours. To the reaction mixture was added water, followed by extraction with methylene chloride and washing of the organic phase in saturated aqueous sodium chloride solution, and dried over magnesium sulfate. Then, the solvent was evaporated off under reduced pressure. The residue obtained was subjected to chromatography on a silica gel column, to yield 0.72 g of ethyl 4-[2-formamido-2-(3-pyridyl)ethyl]cinnamate from a fraction eluted with methanolmethylene chloride (4:96 v/v).

Provenance & Evidence