Sodium Hydroxide → HCID 15232185, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-{4-[2-(4-Chlorobenzenesulfonamido)-2-(3-pyridyl)ethyl]phenyl}propionate (49 mg) was dissolved in a mixed solvent of 1 ml of ethanol and 1 ml of tetrahydrofuran, followed by addition of 0.30 ml of aqueous 2N sodium hydroxide solution, and stirred at 60° C. for 20 minutes. The reaction mixture was concentrated under reduced pressure, which was then adjusted to neutrality with 2N hydrogen chloride. Then, the crystalline deposited was taken out by filtration, and washed in water, followed by drying, to produce 30 mg of 3-{4-[2-(4-chlorobenzenesulfonamido)-2(3-pyridyl)ethyl]phenyl}propionic acid. The spectrometric data supports the structure of [25] as follows.

Provenance & Evidence