HCID 18950663, compound → HCID 18950687, compound

Participants

Reaction Steps

An appropriate amount of Raney nickel was suspended in 30 ml of saturated ammonical methanol solution, followed by addition of 3.81 g of 2-(4-methoxymethyloxyphenyl)-3-(3-pyridyl)propionitrile, and stirred for 72 hours in hydrogen atmosphere of 15 atm. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue obtained was subjected to chromatography on a silica gel column, which was then eluted with aqueous ammonia-methanol-chloroform (1:10:100 v/v), and from the eluted fraction was obtained 3.27 g of 2-(4-methoxymethyloxyphenyl)-3-(3-pyridyl)propylamine.

Provenance & Evidence