Water → HCID 18950755, compound

Participants

Reaction Steps

To the solution of 4.98 g of 3-(4-methoxymethyloxyphenyl)-2-(3-pyridyl)propylamine and 100 ml of the solution of 2.22 g of triethylamine in methylene chloride was added 4.63 g of chlorobenzenesulfonyl chloride, and stirred at room temperature for four hours. The reaction mixture was poured into water, and the organic phase was separated which was then extracted with methylene chloride from aqueous phase. The combined organic phases were washed in saturated aqueous sodium chloride, and dried over magnesium sulfate, to distill off the solvent. The obtained residue was subjected to chromatography on a silica gel column, and from the fraction eluted with methanol-methylene chloride (5:95 v/v) was obtained 3.79 g of N-[3-(4-methoxymethyloxyphenyl)-2-(3-pyridyl)propyl]-4-chlorobenzene sulfonamide.

Provenance & Evidence