Sodium Hydroxide → Phenoxyacetic Acid

Participants

Reaction Steps

Ethyl 4-[(3-(N-ethoxycarbonyl)-4-chlorobenzenesulfonamido]-2-(3-pyridyl)}propyl]phenoxyacetate (181 mg) was dissolved in 2 ml of ethanol, followed by addition of 2 ml of aqueous 1N sodium hydroxide solution, and stirred at room temperature for 24 hours. The reaction mixture was concentrated under reduced pressure. To the residue was added 1N hydrogen chloride for neutralization, and the deposited crystalline was filtered to obtain 89 mg of [3-(4-chlorobenzenesulfonamido)-2-(3-pyridyl)}propyl]phenoxyacetic acid. The spectrometric data supports the structure of [34] as follows.

Provenance & Evidence