Hydrochloric Acid → HCID 18950744, compound

Participants

Reaction Steps

To the solution of 0.72 g of 4-(4-methoxymethyloxyphenyl)-3-(3-pyridyl)butylamine and 0.27 g of triethylamine in methylene chloride, after cooling at 0° C., was added 0.51 g of chlorobenzene sulfonylchloride, and stirred at room temperature for five hours. To the reaction mixture was added water which was then adjusted to weak acidity with 2N hydrogen chloride, and the organic phase was separated which was then extracted from aqueous phase with methylene chloride. The combined organic phases were washed in saturated aqueous sodium chloride solution, and dried over magnesium sulfate, to distill off the solvent. The obtained residue was subjected to chromatography on a silica gel column, and from a fraction eluted with methanol-methylene chloride (5:95 v/v) was obtained 1.02 g of N-[4- (4-methoxymethyloxyphenyl)-3-(3-pyridyl)butyl]-4-chlorobenzenesulfonamide.

Provenance & Evidence