2,6-Dimethyl-8-ethyl-1-deazapurine → HCID 19385688, compound

HRID 1492587Notes

Reaction equation

Br[CH2:2][C:3]1[CH:20]=[CH:19][C:6]([O:7][CH:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]([O:11][CH3:12])=[O:10])=[CH:5][C:4]=1[Cl:21].[CH3:22][C:23]1[N:28]=[C:27]2[N:29]=[C:30]([CH2:32][CH3:33])[NH:31][C:26]2=[C:25]([CH3:34])[CH:24]=1>>[C:9]([CH:8]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[O:7][C:6]1[CH:19]=[CH:20][C:3]([CH2:2][N:29]2[C:27]3=[N:28][C:23]([CH3:22])=[CH:24][C:25]([CH3:34])=[C:26]3[N:31]=[C:30]2[CH2:32][CH3:33])=[C:4]([Cl:21])[CH:5]=1)([O:11][CH3:12])=[O:10]

Participants

Reactant 2

HCID 98153742,6-Dimethyl-8-ethyl-1-deazapurine

HCID 19385653HCID 19385653, compound

Product 1

HCID 19385688HCID 19385688, compoundYield 69.9%

Procedure

The product of Step C (0.116 g, 0.31 mmol) was used to alkylate 0.050 g (0.29 mmol) of 5,7-dimethyl-2-ethylimidazo[4,5-b]pyridine according to the procedure described for Step B of Example 2, which after purification afforded 0.094 g (69%) of the title compound.

Workup

customafter purification

Sources & evidence

ORD record: ord-0e2e0d03d2e942b6a900e2441a1c0dcf
Source dataset: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05374638

Reaction notes

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