HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → HCID 19385701, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Methyl 2-bromo-2-(4-chlorophenyl)acetate | HCID 10777987 | — |
| Reactant | HCID 19385672 | HCID 19385672 | — |
| Reactant | Acetone potassium carbonate | HCID 86600397 | — |
| Product | HCID 19385701 | HCID 19385701 | 50% |
Reaction Steps
Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 4; 5,7-dimethyl-2-ethyl-3-[4-hydroxy-3-propylphenyl methyl]-3H-imidazo[4,5-b]pyridine (Step A, Example 8) was alkylated with methyl 2-bromo-2-(4-chlorophenyl)acetate. Standard workup and purification by flash chromatography afforded a 50% yield of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05374638 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-f2f5376b54674ad389a6f43866599a4f |
| Source note | uspto-grants-1994_12 |