反应详情

To a solution of 6.81 g (21.0 mmol) of the product of Step A dissolved in 75 mL methanol in a high pressure reaction vessel was added 0.3 g 5% palladium on carbon. The resulting suspension was pressurized to 40 psi with H2 and shaken for 2 hours. The solution was filtered through a pad of celite and the filtrate concentrated to a gray-green oil which crystallized on standing. The crude material was flash chromatographed with 50% ethyl acetate/hexane and 3% methanol/ethyl acetate to yield 5.0 g (85%) of the title compound.

1. filtrationThe solution was filtered through a pad of celite
2. concentrationthe filtrate concentrated to a gray-green oil which
3. customcrystallized
4. customchromatographed with 50% ethyl acetate/hexane and 3% methanol/ethyl acetate