Methyl 2-(2-bromophenyl)acetate → Imidazo(4,5-b)pyridine

HRID 1492611Notes

Reaction equation

HRID 1492611 reaction equation
C[C:2]1[N:7]=[C:6]2[N:8](CC3C=CC(NCCC)=CC=3)[C:9](CC)=[N:10][C:5]2=[C:4](C)[CH:3]=1.BrC1C=CC=CC=1CC(OC)=O>>[NH:10]1[C:5]2[C:6](=[N:7][CH:2]=[CH:3][CH:4]=2)[N:8]=[CH:9]1

Participants

3

Reactant 2

HCID 8063364Methyl 2-(2-bromophenyl)acetateHCID 19385717HCID 19385717, compound

Product 1

HCID 67504Imidazo(4,5-b)pyridine

Procedure

Using the general procedure for the phenylaminophenylacetic, acid synthesis described in Step F of Example 25, the product of Step B was alkylated with methyl 2-bromophenylacetate. Standard workup and purification by flash chromatography afforded the title compound.

Workup

  1. customacid synthesis
  2. customStandard workup and purification by flash chromatography

Sources & evidence

ORD record
ord-8e3f7c4acfce4d88aadf2a311e449fab
Source dataset
uspto-grants-1994_12
Patent number
US05374638

Reaction notes

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