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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1492614Generated: November 1, 2026

1-Bromo-2-methylpropane → 3-[4-(N-(1-carbomethoxy-1-phenylmethyl)-N-iso-butylamino)phenylmethyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]-pyridine

https://huagongshe.com/reaction/1492614

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-methylpropaneHCID 6555—
ReactantHCID 10251994HCID 10251994—
Product3-[4-(N-(1-carbomethoxy-1-phenylmethyl)-N-iso-butylamino)phenylmethyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]-pyridineHCID 10254774—

Reaction Steps

Using the general procedure for the alkylation of secondary amines described in Step A of Example 29, 3-[4-(N-(1-carbomethoxy-1-phenylmethylamino)phenylmethyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine (Step A, Example 28) was alkylated with iso-butyl bromide. Standard workup and purification by flash chromatography afforded the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05374638
Source datasetuspto-grants-1994_12
ORD IDord-7d395724660b46339fcdc38cf8e145b4
Source noteuspto-grants-1994_12