HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobutane → 3-[4-(N-(1-carbomethoxy-1-phenylmethyl)-N-sec-butylamino)phenylmethyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobutane | HCID 6554 | — |
| Reactant | HCID 10251994 | HCID 10251994 | — |
| Reactant | HCID 178418261 | HCID 178418261 | — |
| Product | 3-[4-(N-(1-carbomethoxy-1-phenylmethyl)-N-sec-butylamino)phenylmethyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]-pyridine | HCID 10458045 | — |
Reaction Steps
Using the general procedure for the alkylation of secondary amines with LiN(TMS)2 described in Step A of Example 29, 3-[4-(N-(1-carbomethoxy -1-phenylmethyl)amino)phenylmethyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]-pyridine (Step A, Example 28) was alkylated with sec-butyl bromide. Standard workup and purification by flash chromatography afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05374638 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-92e693bd85ce4fb49038156d222c48c9 |
| Source note | uspto-grants-1994_12 |