HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1492620Generated: October 26, 2026
Ammonium Hydroxide → 5-chloro-2-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine
https://huagongshe.com/reaction/1492620
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178437532 | HCID 178437532 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 5-chloro-2-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine | HCID 19385734 | — |
Reaction Steps
A mixture of 29.75 g (0.168 mol) of the product of Step A, CHCl3 (25 mL) and POCl3 (160 mL) was heated to 80° C. for 1 hour. After pouring over ice, the mixture was neutralized by careful addition of NH4OH and extracted with EtOAc. Concentration gave 23.8 g of the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05374638 |
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| Source dataset | uspto-grants-1994_12 |
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| ORD ID | ord-3fae69c4fe5b4ad7b81797eb3df93816 |
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| Source note | uspto-grants-1994_12 |
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