HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1492621Generated: October 27, 2026
Ammonium Hydroxide → 5-Bromo-2-ethyl-7-methyl-1H-imidazo[4,5-b]pyridine
https://huagongshe.com/reaction/1492621
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-chloro-2-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine | HCID 19385734 | — |
| Reactant | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Product | 5-Bromo-2-ethyl-7-methyl-1H-imidazo[4,5-b]pyridine | HCID 19385648 | — |
Reaction Steps
A mixture of 22.2 g (0.113 mol) of the product of Step B in 30% HBr-HOAc was heated to 100° C. for 19 hours. The mixture was poured onto ice, neutralized with NH4OH, extracted (5×EtOAc), and the organic layers were concentrated to give 15 g (1st crop) of the title compound as a solid after crystallization from EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05374638 |
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| Source dataset | uspto-grants-1994_12 |
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| ORD ID | ord-c99c1e333c964f788111466feda8c7d0 |
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| Source note | uspto-grants-1994_12 |
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