反应详情

To a solution of 1.260 g (3.79 mmol) of the product of Step A in 8 mL methanol was added 0.072 g (1.90 mmol) of sodium borohydride and the reaction mixture was stirred at room temperature for 15 minutes. Excess borohydride was quenched with water, and the reaction mixture was extracted into EtOAc. The organic layer was dried (MgSO4), filtered, evaporated, and then purified on a silica gel flash chromatography column eluted with 30% EtOAc-hexane. The purified fractions were combined, evaporated and dried in vacuo to afford 0.790 g (63%) of the title compound.

1. customExcess borohydride was quenched with water
2. extractionthe reaction mixture was extracted into EtOAc
3. dry with materialThe organic layer was dried (MgSO4)
4. filtrationfiltered
5. customevaporated
6. custompurified on a silica gel flash chromatography column
7. washeluted with 30% EtOAc-hexane
8. customevaporated
9. customdried in vacuo