Hydrochloric Acid → HCID 18950599, compound

Participants

Reaction Steps

To a magnetically stirred solution of 0.280 g (0.56 mmol) of the product of Step D in 4.0 mL methanol was added 0.5 mL of a 5.0N solution of sodium hydroxide and the reaction was stirred at room temperature for 1.5 hours. The reaction mixture was adjusted to pH=6 with 1.0N hydrochloric acid and then concentrated in vacuo. The residue was then purified on a silica gel flash chromatography column eluted with CHCl3 --MeOH--NH4OH (80:15:1). Evaporation of the purified fractions and drying in vacuo afforded 0.238 g (87%) of the title compound.

Provenance & Evidence