Benzene, 1-(chloromethyl)-2-fluoro- → HCID 2986847, compound

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Reaction Steps

In a procedure as in Example 2 but using 1H-benzotriazole (34.5 g, 0.289 mol) and 1-(chloromethyl)-2-fluorobenzene (41.8 g, 0.289 mol) for 1h gave the title compound and (2-fluorophenyl)methyl-2H-benzotriazole in a ratio of 80:20. Similar workup and recrystallization gave the pure 1H-isomer (73%): mp 93°-95° C. (cyclohexane); 1H NMR (270 MHz, CDCl3) δ5.93 (s, 2H, CH2), 7.08-7.47 (m, 7H), 8.10 (d, J=7.2 Hz, 1H).

Provenance & Evidence