Glyoxylic Acid → HCID 11023864, compound

HRID 1492685Notes

Reaction equation

HRID 1492685 reaction equation
[CH2:1]([C:3]1[C:8]([NH2:9])=[C:7]([CH3:10])[CH:6]=[CH:5][CH:4]=1)[CH3:2].[C:11]([OH:15])(=[O:14])[CH:12]=O>CO>[NH2:9][C:8]1[C:3]([CH2:1][CH3:2])=[CH:4][C:5]([CH:12]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8]([NH2:9])=[C:7]([CH3:10])[CH:6]=2)[C:11]([OH:15])=[O:14])=[CH:6][C:7]=1[CH3:10]

Participants

4

Reactant 2

HCID 760Glyoxylic AcidHCID 324852-Ethyl-6-methylaniline

Product 1

HCID 11023864HCID 11023864, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 6-ethyl-2-methylaniline (30.0 parts) and methanol (100 parts) was stirred at ambient temperature. Glyoxylic acid 50% w/v (16.5 parts) was added and the mixture was stirred for 24 hours at ambient temperature. The precipitated product was isolated by filtration, washed with methanol (20 parts) and dried to yield di(4-amino-5-ethyl-3-methylphenyl)acetic acid (31.0 parts).

Workup

  1. additionwas added
  2. stirringthe mixture was stirred for 24 hours at ambient temperature
  3. customThe precipitated product was isolated by filtration
  4. washwashed with methanol (20 parts)
  5. customdried

Sources & evidence

ORD record
ord-d3b3364b53c14dc9a01e75901d7158f0
Source dataset
uspto-grants-1994_12
Patent number
US05374724

Reaction notes

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