Glyoxylic Acid → HCID 18951350, compound

HRID 1492686Notes

Reaction equation

HRID 1492686 reaction equation
[C:1]([OH:5])(=[O:4])[CH:2]=O.O.[CH2:7]([C:9]1[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=1[NH2:11])[CH3:8]>CO>[NH2:11][C:10]1[CH:12]=[CH:13][C:14]([CH:2]([C:14]2[CH:13]=[CH:12][C:10]([NH2:11])=[C:9]([CH2:7][CH3:8])[CH:15]=2)[C:1]([OH:5])=[O:4])=[CH:15][C:9]=1[CH2:7][CH3:8]

Participants

5

Reactant 3

HCID 760Glyoxylic AcidHCID 962WaterHCID 113572-Ethylaniline

Product 1

HCID 18951350HCID 18951350, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of glyoxylic acid 50% w/v (3.05 parts), water (20 parts) and methanol (10 parts) was stirred at ambient temperature. 2-ethylaniline (5.0 parts) was added and the mixture was stirred under reflux for 2 hours. After cooling to ambient temperature, the product was isolated by filtration, washed with a little water (50 parts) and dried to yield di(4-amino-3-ethylphenyl)acetic acid (5.5 parts).

Workup

  1. stirringthe mixture was stirred
  2. temperatureunder reflux for 2 hours
  3. temperatureAfter cooling to ambient temperature
  4. customthe product was isolated by filtration
  5. washwashed with a little water (50 parts)
  6. customdried

Sources & evidence

ORD record
ord-eff9b433390c4bdd8c1fbb27c027ba78
Source dataset
uspto-grants-1994_12
Patent number
US05374724

Reaction notes

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