Ethyl 3-oxohexanoate → HCID 178450613, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium nitrite (2.94) in water (7 ml) was added over 1.5 h at 25°-30° C. to a stirred solution of ethyl 3-oxohexanoate (5.0 g) in glacial acetic acid (6 ml). The orange mixture was stirred at 25° C. for 0.5 h before dilution with water (2 ml) and stirring at 20° C. for 15.5 h. The mixture was extracted with ether (2×20 ml) and the combined extracts washed with water (20 ml), 8% sodium bicarbonate (2×20 ml) and saturated sodium chloride solution (20 ml). The yellow solution was then dried and evaporated in vacuo, to afford a mobile yellow oil (4.95 g).

Provenance & Evidence