Sodium Hydroxide → HCID 15680841, compound

HRID 1492764Notes

Reaction equation

HRID 1492764 reaction equation
[OH-].[Na+].[Br:3][C:4]1[C:8]2[CH:9]=[C:10]([CH2:13][N:14]3[C:18]([C:19]([OH:21])=[O:20])=[C:17]([Cl:22])[N:16]=[C:15]3[CH2:23][CH2:24][CH2:25][CH3:26])[CH:11]=[CH:12][C:7]=2[O:6][C:5]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:33]([O:35]CC)=[O:34]>O.C(O)C>[Br:3][C:4]1[C:8]2[CH:9]=[C:10]([CH2:13][N:14]3[C:18]([C:19]([OH:21])=[O:20])=[C:17]([Cl:22])[N:16]=[C:15]3[CH2:23][CH2:24][CH2:25][CH3:26])[CH:11]=[CH:12][C:7]=2[O:6][C:5]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:33]([OH:35])=[O:34]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 18950981HCID 18950981, compound

Product 1

HCID 15680841HCID 15680841, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Sodium hydroxide (89 mg) in water (0.2 ml) was added to a suspension of the product of Example 51 (0.5 g) in ethanol (5 ml). The solution was heated under reflux for 16 h, cooled, then evaporated in vacuo. The residue was dissolved in water (5 ml), and HCl (2N; 1 ml) was added dropwise resulting in the precipitation of the title compound which was filtered off, washed with water (2×5 ml) and dried to give the title compound as a colourless solid (391 mg). m.p. 148°-152° C.

Workup

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 16 h
  3. temperaturecooled
  4. customevaporated in vacuo
  5. dissolutionThe residue was dissolved in water (5 ml)
  6. additionHCl (2N; 1 ml) was added dropwise

Sources & evidence

ORD record
ord-d02a64bfa2ad48b795656022e35952b8
Source dataset
uspto-grants-1994_12
Patent number
US05374646

Reaction notes

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