Sodium Hydroxide → HCID 178441619, compound

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Reaction Steps

The product of Example 67 (220 mg) was dissolved in methanol (10 ml). 2N aqueous sodium hydroxide (10 ml) was added followed by methanol (~1 ml) to effect complete dissolution. The mixture was stirred at room temperature for 24 h, diluted with water (20 ml), washed with ether (3×20 ml) and then acidified to pH4 by the dropwise addition of 2N hydrochloric acid. The resultant precipitate was collected, washed with water on the filter pad, and dried in vacuo to give the title compound as a white amorphous solid (0.16 g).

Provenance & Evidence