Potassium Carbonate → HCID 53921746, compound

Participants

Reaction Steps

A mixture of 0.60 (1.2 mmol) of 3-hydroxy-5-(octadecyloxy) benzoic acid phenylmethyl ester, 0.46 g (1.27 mmol) of 6-[(4-phenylmethoxy)phenoxy]hexyl bromide and 0.3 g (2.17 mmol) of potassium carbonate in 20 ml of acetone and 1 ml of DMF was stirred at reflux for 21 hours. The usual workup followed by chromatography on 40 g of silica gel (230-400 mesh) using 5% ethyl acetate-hexane gave 0.7 g (74% yield, mp 60°-62°) of 3-(octadecyloxy)-5-[[6-[4-(phenylmethoxy)phenoxy]hexyl]oxy]benzoic acid phenylmethyl ester.

Provenance & Evidence