HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 2553006, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- | HCID 11325 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 178418793 | HCID 178418793 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 2553006 | HCID 2553006 | 93.4% |
Reaction Steps
A mixture of 2-mercaptopyrimidine (7.3 g), N-(2-bromoethyl)phthalimide (16.5 g), potassium carbonate (10.8 g) and N,N-dimethylformamide (DMF) (85 ml) was stirred at room temperature for 3 hours. The reaction mixture was poured into water and the crystals separated were collected by filtration to obtain N-[2-(2-pyrimidinylthio)ethyl]-phthalimide (17.3 g, 93%). The resultant was recrystallized from ethanol-isopropyl ether to obtain pale yellow prisms, m.p. 149°-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05376647 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-ba84abc712734104ac58a8c14f29fadd |
| Source note | uspto-grants-1994_12 |