HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Sulfite → TetraiSopropyl (chloromethylene)bis(phosphonate)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | 2-((Dichloro-di(propan-2-yloxy)phosphorylmethyl)-propan-2-yloxyphosphoryl)oxypropane | HCID 4193748 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | TetraiSopropyl (chloromethylene)bis(phosphonate) | HCID 13479864 | — |
Reaction Steps
Into a solution containing 8.2 g (0.02 moles) of tetraisopropyl (dichloromethylene)bisphosphonate in 70 ml of ethanol, 9.0 g of sodium sulphite in 250 ml of water are added while stirring during 15 minutes at 10° to 15° C., whereafter the mixture is stirred for 1 h. The mixture is extracted with chloroform and the extract is dried (MgSO4) and filtered. The filtrate is evaporated under a vacuum, whereby about 7.6 g (100% of the theor.) of tetraisopropyl (monochloromethylene)bisphosphonate (31P-NMR (CDCl3 : δ 12.04 ppm) are obtained as a colourless oil, at a concentration of 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05376649 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-a154b0c6eec747718c9077029962df67 |
| Source note | uspto-grants-1994_12 |