HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1492939Generated: October 26, 2026
Acetone, oxime → acetone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio)-alpha-methylbenzyl}oxime
https://huagongshe.com/reaction/1492939
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone, oxime | HCID 67180 | — |
| Reactant | 4-{3-[4-(1-Chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran | HCID 19379931 | — |
| Product | acetone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio)-alpha-methylbenzyl}oxime | HCID 9909885 | 58% |
Reaction Steps
Using an analogous procedure to that described in Example 1 except that the reactants were heated to 60° C. for 2 hours, acetone oxime was reacted with 4-{3-[4-(1-chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran to give acetone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio)-α-methylbenzyl}oxime as an oil in 58% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05376680 |
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| Source dataset | uspto-grants-1994_12 |
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| ORD ID | ord-eb32913a49604aa78cf550693e028e28 |
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| Source note | uspto-grants-1994_12 |
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