Benzophenone oxime → HCID 19379938, compound

HRID 1492940Notes

Reaction equation

[C:1](=[N:14][OH:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([S:24][C:25]2[CH:26]=[C:27]([C:32]3([O:38][CH3:39])[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[CH:28]=[C:29]([F:31])[CH:30]=2)=[CH:20][CH:19]=1>>[F:31][C:29]1[CH:28]=[C:27]([C:32]2([O:38][CH3:39])[CH2:33][CH2:34][O:35][CH2:36][CH2:37]2)[CH:26]=[C:25]([S:24][C:21]2[CH:22]=[CH:23][C:18]([CH2:17][O:15][N:14]=[C:1]([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:19][CH:20]=2)[CH:30]=1

Participants

Reactant 2

HCID 11324Benzophenone oxime

HCID 19379941HCID 19379941, compound

Product 1

HCID 19379938HCID 19379938, compoundYield 44%

Procedure

Using an analogous procedure to that described in Example 1, benzophenone oxime was reacted with 4-[3-(4-chloromethylphenylthio)-5fluorophenyl]-4-methoxytetrahydropyran to give benzophenone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]benzyl}oxime as an oil in 44% yield.

Sources & evidence

ORD record: ord-a19ee73e9e51437c8e936ff8d3097eb6
Source dataset: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05376680

Reaction notes

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