HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(oxan-4-ylidene)hydroxylamine → tetrahydropyran-4-one O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-alpha-methylbenzyl}oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(oxan-4-ylidene)hydroxylamine | HCID 12298558 | — |
| Reactant | 4-{3-[4-(1-Chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran | HCID 19379931 | — |
| Product | tetrahydropyran-4-one O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-alpha-methylbenzyl}oxime | HCID 19379937 | 74% |
Reaction Steps
Using an analogous procedure to that described in Example 1, tetrahydropyran-4-one oxime was reacted with 4-{3-[4-(1-chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran to give tetrahydropyran-4-one O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α-methylbenzyl}oxime as an oil in 74% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05376680 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-68ce202b88454e78bf074fbdfe5a1f4e |
| Source note | uspto-grants-1994_12 |