Acetone, oxime → HCID 19379944, compound

HRID 1492944Notes

Reaction equation

[CH3:1][C:2](=[N:4][OH:5])[CH3:3].Cl[CH2:7][C:8]1[CH:30]=[CH:29][C:11]([CH2:12][O:13][C:14]2[CH:15]=[C:16]([C:21]3([O:27][CH3:28])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)[CH:17]=[C:18]([F:20])[CH:19]=2)=[CH:10][CH:9]=1>>[F:20][C:18]1[CH:17]=[C:16]([C:21]2([O:27][CH3:28])[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[CH:15]=[C:14]([CH:19]=1)[O:13][CH2:12][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][O:5][N:4]=[C:2]([CH3:3])[CH3:1])=[CH:30][CH:29]=1

Participants

Reactant 2

HCID 67180Acetone, oxime

HCID 19379939HCID 19379939, compound

Product 1

HCID 19379944HCID 19379944, compoundYield 72%

Procedure

Using an analogous procedure to that described in Example 1, acetone oxime was reacted with 4-[3-(4-chloromethylbenzyloxy)-5-fluorophenyl]-4-methoxytetrahydropyran to give acetone O-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenoxymethyl]benzyl}oxime as a gum in 72% yield.

Sources & evidence

ORD record: ord-e5eb0fb6b48a435bb88d52bdd48eadb4
Source dataset: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05376680

Reaction notes

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