Acetone, oxime → HCID 19379947, compound

HRID 1492945Notes

Reaction equation

[CH3:1][C:2](=[N:4][OH:5])[CH3:3].[Cl:6][C:7]1[CH:8]=[C:9]([S:15][C:16]2[CH:17]=[C:18]([C:23]3([O:29][CH3:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:19]=[C:20]([F:22])[CH:21]=2)[CH:10]=[CH:11][C:12]=1[CH2:13]Cl>>[Cl:6][C:7]1[CH:8]=[C:9]([S:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([C:23]3([O:29][CH3:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:17]=2)[CH:10]=[CH:11][C:12]=1[CH2:13][O:5][N:4]=[C:2]([CH3:3])[CH3:1]

Participants

Reactant 2

HCID 67180Acetone, oxime

HCID 19379935HCID 19379935, compound

Product 1

HCID 19379947HCID 19379947, compoundYield 50%

Procedure

Using an analogous procedure to that described in Example 1, acetone oxime was reacted with 4-[3-(3-chloro-4-chloromethylphenylthio)-5-fluorophenyl]-4-methoxytetrahydropyran to give acetone O-{2-chloro-4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]benzyl}oxime as a gum in 50% yield.

Sources & evidence

ORD record: ord-6a4656e56eab43df87b53d9230c6b305
Source dataset: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05376680

Reaction notes

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