Water → HCID 57259263, compound

Participants

Reaction Steps

To a stirred solution of 17-Allyl-1-hydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-14,18-diene-2,3,10,16-tetraone (as prepared in Example 14) (100 mg) in toluene (5 ml) and acetic acid (0.01 ml) was added tetrakis(triphenylphosphine) palladium(0) (0.01 g). After 5 minutes tri n-butyltin hydride (0.04 g) was added and the reaction mixture was stirred at room temperature for 2 hours. Water was added and the reaction mixture was extracted with ether. The ether extracts were dried (magnesium sulphate), filtered and evaporated to an oil in vacuo. Chromatography on silica eluting with ether gave the title compound as a low melting solid (70 mg).

Provenance & Evidence