HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → HCID 57261554, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 17-Allyl-1-hydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacosa-14,18-diene-2,3,10,16-tetraone | HCID 57153457 | — |
| Catalyst | Boron trifluoride etherate | HCID 8000 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57261554 | HCID 57261554 | 5.7% |
Reaction Steps
To a solution of the title compound of Example 14 (823 mg, 1.05 mmole) in dry dichloromethane (50 ml) was added boron trifluoride diethyl etherate (1 drop) followed by portionwise addition of a dried solution of diazomethane in diethyl ether until no starting material remained. Sodium carbonate was then added, and the resulting mixture stirred for 30 minutes at room temperature. The reaction mixture was then filtered, concentrated in vacuo, and chromatographed on silica eluting with 40°-60° petroleum ether/ethyl acetate [3:1] to give the title compound as an oil (45 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05376663 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-88bb936c31d940818674d701ea3db251 |
| Source note | uspto-grants-1994_12 |