反应详情

温度

120 °C

Compound I (219 g) is slowly added to anhydrous AlCl3 (720 g) under nitrogen and kept at room temperature while stirred. Stirring is discontinued when the mixture becomes too viscous. After heating to 120° C. for 1 h, stirring is re-started again and the temperature is further increased to 180° C. (2 hrs). After cooling and addition of excess water, the product is steam-distilled. Extraction with chloroform and evaporation gives 127 g of crude II.

1. customkept at room temperature
2. stirringStirring
3. stirringstirring
4. temperaturethe temperature is further increased to 180° C. (2 hrs)
5. temperatureAfter cooling
6. distillationthe product is steam-distilled
7. extractionExtraction
8. customwith chloroform and evaporation