Diethyl Ether → HCID 18950034, compound

Participants

Reaction Steps

1-iodopropane (0.89 ml) is added to a mixture of (+)-VII·HCl (1.01 g) and powdered potassium carbonate in 30 ml MeCN under nitrogen. The mixture is stirred at room temperature for 10 days during which two portions of 0.3 ml 1-iodopropane is added. After addition of diethyl ether, filtration and evaporation, the crude product purified by chromatography on alumina (diethyl ether/light petroleum, 1:4) to give 0.90 g of (+)-VIII·HCl and, on further elution, 0.23 g of (+)-5-fluoro-8-methoxy-2-propylaminotetralin hydrochloride, (+)-XI·HCl.

Provenance & Evidence