HCID 18652786, compound → HCID 6540749, compound

Participants

Reaction Steps

20 mg of 5% palladium-on-carbon are added to a solution of 0.125 g of 3-{N-[1-(3,4-dichlorophenyl)ethyl]amino}-2-(S)-hydroxy-propyl-(cyclohex-3-enylmethyl)-phosphinic acid in 5 ml of ethanol and hydrogenation at room temperature and normal pressure for 15 minutes. The catalyst is filtered off through Celite® and the filtrate is adjusted to pH 1 with ethanolic hydrochloric acid. Removal of the solvent and recrystallisation from isopropanol yield 3-{N-[1-(3,4-dichlorophenyl)ethyl]amino}-2(S)-hydroxypropyl-(cyclohexylmethyl)-phosphinic acid, m.p. 173°-178°.

Provenance & Evidence