反应详情

To 20 g of N1 -cyano-N3 -octyl-guanidine and 20.2 g of 3,4-dichlorobenzylamine hydrochloride, 200 ml of mesitylene was added, which was heated and refluxed for 1.5 hours. Returning to room temperature after reaction, mesitylene was removed. To the residue, 200 ml of 10% ethanol aqueous solution was added, which was heated, and stirred for 3 hours at room temperature to be solidified. It was filtered off, and washed with 10% ethanol solution, water and isopropylether in turn, and 28.1 g of rough product was obtained. It was recrystallized in ethyl acetate, and 22.1 g of the captioned compound was obtained.

1. temperaturewhich was heated
2. temperaturerefluxed for 1.5 hours
3. customwas removed
4. additionTo the residue, 200 ml of 10% ethanol aqueous solution was added
5. temperaturewhich was heated
6. filtrationIt was filtered off
7. washwashed with 10% ethanol solution, water and isopropylether in turn