Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 149299Generated: October 27, 2026

Water → 4-(9'-cyclohexyl-5'-methyl-6'-oxo-5',6',8',9'-tetrahydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepine]-2'-ylamino)-3-fluoro-N-(1-methyl-4-piperidyl)benzamide

https://huagongshe.com/reaction/149299

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
Reactantp-Toluenesulfonic acidHCID 6101—
Reactant4-Methyl-2-PentanolHCID 7910—
Reactant2'-chloro-9'-cyclohexyl-5'-methyl-8',9'-dihydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepin]-6'(5'H)-oneHCID 57969884—
Reactant4-amino-3-fluoro-N-(1-methyl-4-piperidyl)benzamideHCID 62679846—
Product4-(9'-cyclohexyl-5'-methyl-6'-oxo-5',6',8',9'-tetrahydrospiro[cyclopropane-1,7'-pyrimido[5,4-b][1,4]diazepine]-2'-ylamino)-3-fluoro-N-(1-methyl-4-piperidyl)benzamideHCID 68683538—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-523e07f0a727464f9e1c9a69ec0b1a82
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)