HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → HCID 54508459, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 86747359 | HCID 86747359 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 54508459 | HCID 54508459 | 84.9% |
Reaction Steps
A solution of 33.5 mg of (S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl hydrogen malonate (Example N) in 2 ml of acetonitrile was treated with 60 mg of HBTU and 75 mg of iso- propylamine. After stirring the reaction mixture was filtered, the filtrate was concentrated and the residue was chromatographed on silica gel with hexane/methylene chloride/ethyl acetate (2:2:1). There were obtained 31.1 mg of (S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl-N-isopropylmalonamate, m.p. 59°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05376674 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-6866857dc28b43d18c5f6b93f8dfb23a |
| Source note | uspto-grants-1994_12 |