Sodium Hydroxide → HCID 19735070, compound

HRID 1493125Notes

Reaction equation

HRID 1493125 reaction equation
[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[C:10]([CH3:14])=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:15]=[N:16][C:17]([C:18]([O:20]CC)=[O:19])=[C:4]2[CH2:3]1.[OH-].[Na+]>C(O)C.O>[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[C:10]([CH3:14])=[CH:11][CH:12]=[CH:13][C:6]=2[N:5]2[CH:15]=[N:16][C:17]([C:18]([OH:20])=[O:19])=[C:4]2[CH2:3]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 19735052HCID 19735052, compound

Product 1

HCID 19735070HCID 19735070, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

25 g (85 mmol) of ethyl 5,6-dihydro-5,7-dimethyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate were heated to boiling under reflux for 1 hour with 3.40 g (85 mmol) of sodium hydroxide in 200 ml of ethanol and 15 ml of water. After evaporation of the ethanol the mixture was diluted with water and acidified with 21 ml of 4 normal hydrochloric acid. The suspension obtained was suction filtered and washed with water. After drying the suction filter cake there was obtained 5,6-dihydro-5,7-dimethyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid of decomposition point 274-275°.

Workup

  1. customAfter evaporation of the ethanol the mixture
  2. additionwas diluted with water
  3. customThe suspension obtained
  4. filtrationfiltered
  5. washwashed with water
  6. customAfter drying the suction
  7. filtrationfilter cake

Sources & evidence

ORD record
ord-7a3d607485cf4cb3afa5fde7f88b2a9c
Source dataset
uspto-grants-1991_06
Patent number
US05021411

Reaction notes

Loading…