HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiopheneacetyl chloride → 3-(Pyrrolidin-1-ylmethyl)-4-(2-thienylacetyl)thiomorpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiopheneacetyl chloride | HCID 162362 | — |
| Reactant | 3-(Pyrrolidin-1-ylmethyl)thiomorpholine | HCID 15730147 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-(Pyrrolidin-1-ylmethyl)-4-(2-thienylacetyl)thiomorpholine hydrochloride | HCID 18915000 | 19.9% |
Reaction Steps
The procedure described in Example 17 was repeated, but using 1.0 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 2.49 ml of triethylamine and 1.03 g of 2-thienylacetyl chloride, to afford 0.37 g of the title compound, melting at 204°-206° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05021413 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-03f8b3a584bc4ed78f63742ed1f6b084 |
| Source note | uspto-grants-1991_06 |