HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 2-[3-[3-(N,N-Dimethylaminomethyl)phenoxy]propyl]-1H-isoindole-1,3(2H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 3-(3-(1,3-Dioxoisoindolin-2-yl)propoxy)benzaldehyde | HCID 12810640 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[3-[3-(N,N-Dimethylaminomethyl)phenoxy]propyl]-1H-isoindole-1,3(2H)-dione | HCID 12810611 | — |
Reaction Steps
2-[3-[3-(Formyl)phenoxy]propyl]-1H-isoindole-1,3(2H) dione (132 g) and 33% ethanolic dimethylamine (300 ml) were hydrogenated at room temperature and atmospheric pressure in ethanol over 10% palladium on charcoal. The catalyst was filtered off and the filtrate evaporated to give the title compound as a yellow oil (142 g). TLC silica (ethyl acetate) Rf 0.35, m.p. (oxalate salt) 204°-207°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05021429 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-2fd0fd6ad18d4f8da6d9533d3ecf31a7 |
| Source note | uspto-grants-1991_06 |