Methylamine → 3-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine

Participants

Reaction Steps

2-[3-[3-(N,N-Dimethylaminomethyl)phenoxy]propyl]-1H-isoindole-1,3(2H)-dione (25 g) was treated with 30% ethanolic methylamine (150 ml). After 24 hr at room temperature ether (100 ml) was added and a solid was filtered off. The filtrate was distilled to give the title compound as a yellow oil (12.3 g) b.p. 102°-112° (0.2 mm). TLC silica; ethyl acetate:isopropanol:water:0.88 ammonia Rf 0.25.

Provenance & Evidence