反应详情

1.00 g of N-chloromethyl-N-(4-methylphenyl)carbamoyl chloride and 1.45 g of 1-(4-trifluoromethylbenzyl)-3-(2,2,2-trifluoroethyl)thiourea were dissolved in 30 ml of benzene, and the solution was heated under reflux for 4 hours. After the reaction, benzene was evaporated under reduced pressure. The resulting oily product was purified by column chromatography [silica gel; eluent: hexane/ethyl acetate (10/1)] to give 1.27 g of the captioned compound.

1. temperaturethe solution was heated
2. temperatureunder reflux for 4 hours
3. customwas evaporated under reduced pressure
4. customThe resulting oily product was purified by column chromatography [silica gel; eluent: hexane/ethyl acetate (10/1)]