1-(1,1-Dimethylethyl) 2-methyl 1,2-piperazinedicarboxylate → HCID 86603316, compound

HRID 14932Notes

Reaction equation

HRID 14932 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[CH3:16][O:17][C:18]([CH:20]1[CH2:25][NH:24][CH2:23][CH2:22][N:21]1[C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])=[O:19]>>[CH3:16][O:17][C:18]([CH:20]1[CH2:25][N:24]([CH2:11][C:10]2[CH:13]=[CH:14][CH:15]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=2)[CH2:23][CH2:22][N:21]1[C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])=[O:19]

Participants

3

Reactant 2

HCID 27568181-(1,1-Dimethylethyl) 2-methyl 1,2-piperazinedicarboxylateHCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

Product 1

HCID 86603316HCID 86603316, compound

Procedure

Intermediate 1 was coupled with piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 447.

Sources & evidence

ORD record
ord-5ee1f48a7f70479ea91598226b80858e
Source dataset
uspto-grants-2010_06
Patent number
US07732444B2

Reaction notes

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