反应详情

0.71 g of N-chloromethyl-N-(4-methylphenyl)carbamoyl chloride and 1.20 g of 1-(4-pentafluoroethylbenzyl)-3-(2,2,2-trifluoroethyl)thiourea were dissolved in 30 ml of toluene, and the solution was heated under reflux for 4 hours. After the reaction, toluene was evaporated under reduced pressure. The resulting oily product was purified by column chromatography silica gel; developing solvent hexane/ethyl acetate (10:1)]to give 0.72 g of the captioned compound.

1. temperaturethe solution was heated
2. temperatureunder reflux for 4 hours
3. customwas evaporated under reduced pressure
4. customThe resulting oily product was purified by column chromatography silica gel