Ethanamine, 2,2,2-trifluoro- → HCID 14801043, compound

HRID 1493205Notes

Reaction equation

HRID 1493205 reaction equation
[C:1]([C:5]1[CH:15]=[CH:14][C:8]([C:9]([N:11]=[C:12]=[S:13])=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:16][C:17]([F:21])([F:20])[CH2:18][NH2:19]>>[C:1]([C:5]1[CH:15]=[CH:14][C:8]([CH2:9][NH:11][C:12]([NH:19][CH2:18][C:17]([F:21])([F:20])[F:16])=[S:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 27953844-Tert-butylbenzoyl isothiocyanate

Product 1

HCID 14801043HCID 14801043, compoundYield 105.2%

Procedure

10.82 g of 4-t-butylbenzoyl isothiocyanate obtawined in (1) and 7.54 g of 2,2,2-trifluoroethylamine were dissolved in 20 ml of ethyl acetawte. The solution was left to stand at room temperature for 24 houirs. Ethyl acetate was evaporated under reduced prerssure. The resultilng oily product was purified by column chromatography silica gel; developing solvent hexane/ethyl acetate (4:1)) to give 15.80 g of the desired 1-(4-t-butylbenzyl)-3-(2,2,2-trifluoroethyl)thiourea.

Workup

  1. dissolutionwere dissolved in 20 ml of ethyl acetawte
  2. waitThe solution was left
  3. customto stand at room temperature for 24 houirs
  4. customEthyl acetate was evaporated under reduced prerssure
  5. customThe resultilng oily product was purified by column chromatography silica gel

Sources & evidence

ORD record
ord-33224c63a543431fa998cd259b2bfb6c
Source dataset
uspto-grants-1991_06
Patent number
US05021412

Reaction notes

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