Carbon Disulfide → 4-Pentafluoroethylbenzyl isothiocyanate

HRID 1493208Notes

Reaction equation

HRID 1493208 reaction equation
[F:1][C:2]([F:15])([C:7]1[CH:14]=[CH:13][C:10]([CH2:11][NH2:12])=[CH:9][CH:8]=1)[C:3]([F:6])([F:5])[F:4].C1CCC(N=C=NC2CCCCC2)CC1.[C:31](=S)=[S:32]>C(OCC)C>[F:1][C:2]([F:15])([C:7]1[CH:14]=[CH:13][C:10]([CH2:11][N:12]=[C:31]=[S:32])=[CH:9][CH:8]=1)[C:3]([F:5])([F:4])[F:6]

Participants

5

Reactant 3

HCID 6348Carbon DisulfideHCID 10868DicyclohexylcarbodiimideHCID 147741864-(Pentafluoroethyl)benzylamine

Product 1

HCID 147741874-Pentafluoroethylbenzyl isothiocyanate

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
-10 °C

Procedure

4.7 g of 4-pentafluoroethylbenzylamine was added dropwise to a mixture of 4.8 g of DCC, 20 ml of carbon disulfide and 50 ml of diethyl ether with stirring at -10° C. The temperature of the mixture was returned to room temperature, and it was left to stand for 12 hours.

Workup

  1. customwas returned to room temperature
  2. waitit was left

Sources & evidence

ORD record
ord-eb940a1899ab4a51808e3ba1d4da4baf
Source dataset
uspto-grants-1991_06
Patent number
US05021412

Reaction notes

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