Formaldehyde → HCID 15282209, compound

HRID 1493218Notes

Reaction equation

HRID 1493218 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][N:6]=[C:5]([CH2:10][S:11]([C:13]2[NH:17][C:16]3[CH:18]=[CH:19][CH:20]=[CH:21][C:15]=3[N:14]=2)=[O:12])[C:4]=1[CH3:22].[CH2:23]=[O:24]>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][N:6]=[C:5]([CH2:10][S:11]([C:13]2[N:14]([CH2:23][OH:24])[C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)=[O:12])[C:4]=1[CH3:22]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 99487972-[[(4-Methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

Product 1

HCID 15282209HCID 15282209, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[[(4-Methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (3.15 g, 10 mmoles) and N,N-dimethylaminopyridine (120 mg, 1 mmol) was dissolved in methylene chloride (50 ml). A solution of formaldehyde (5M, 10 ml, 50 mmol) was added and the mixture was stirred violently for 2 minutes. The phases were separated and the methylene chloride solution was dried (sodium sulphate), filtered and evaporated to dryness. The slightly red residue was the title compound as an essentially pure oil.

Workup

  1. customThe phases were separated
  2. dry with materialthe methylene chloride solution was dried (sodium sulphate)
  3. filtrationfiltered
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-cbee829eb19e4014a2776b74a7562e26
Source dataset
uspto-grants-1991_06
Patent number
US05021433

Reaction notes

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