Azane;hydrate → HCID 14514397, compound

Participants

Reaction Conditions

Reaction Steps

0.04 g of bromine compound (of example 1) is dissolved in 2 ml of N- methylpyrrolidine, 0.05 g of copper(I) cyanide is added and stirred under argon for 5 hours at 180° C. Ammonia water is added to the reaction solution and then extracted with ethyl acetate. The organic phase is concentrated by evaporation in a vacuum and the remaining oil is distilled on a bulb tube, boiling point 180° C./0.03 mbar. 0.01 g of 5-[1-(1-imidazolyl)-butyl]thiophene-2-carbonitrile is obtained.

Provenance & Evidence