Ammonia → HCID 14514399, compound

Participants

Reaction Conditions

Reaction Steps

0.3 g of 2-[1-(1-imidazolyl)-butyl]-4-bromothiophene is dissolved in 5 ml of N-methylpyrrolidine and mixed with 0.3 g of copper(I) cyanide and stirred for 5 hours at 180° C. Then the reaction mixture is poured into 100 ml of dilute ammonia solution and extracted with ethyl acetate. The ethyl acetate phase is concentrated by evaporation in a vacuum and distilled on a bulb tube, boiling point 180° C./0.03 mbar. 0.190 g of 2-[1-(1-imidazolyl)-butyl]-thiophene-4-carbonitrile is obtained.

Provenance & Evidence